Vascular Closure Engineered for Electrophysiology & Large-Bore Access
SiteSeal® is the only FDA-cleared device with no sheath size limitation, delivering secure hemostasis while leaving nothing behind. Designed for the demands of complex EP procedures, structural heart, and large-bore interventions (EVAR, TEVAR, TAVI), it reduces access-site complications, accelerates ambulation, and improves outcomes in high-volume labs.
Why EP Labs & Interventionalists Choose SiteSeal®
- No implant left behind
Eliminates embolization, infection, or vessel injury risk
- No Sheath size limitation
- Proven in EP
- Faster closure, faster turnover
Typically under 5 minutes from sheath pull to hemostasis, freeing the cath lab for the next case
- Rapid recovery
Immediate 30° head elevation, unrestricted leg movement, early ambulation
In a 138-patient EP study (AHA Circulation abstract):
- Cost-effective
Backed by Comparative Data
In a 138-patient EP study (AHA Circulation abstract):
SiteSeal® vs Perclose (suture) vs Vascade (collagen plug) showed:
- No significant arterial complication differences
- SiteSeal®: zero hematomas or delayed bleeding
- Comparable venous outcomes and ambulation time
SiteSeal® vs Leading Competitors
Backed by Comparative Data
In a 138-patient EP study (AHA Circulation abstract):
SiteSeal® vs Perclose (suture) vs Vascade (collagen plug) showed:
- No significant arterial complication differences
- SiteSeal®: zero hematomas or delayed bleeding
- Comparable venous outcomes and ambulation time
SiteSeal® vs Leading Competitors
See how SiteSeal® stacks up against Perclose ProGlide, Angio-Seal, Mynx, Vascade, and figure of eight in sheath compatibility, implant profile, and EP performance.
Comparison
Perclose
ProGlide
Angio-Seal
MVP
No
(suture)
(plug)
(sealant)
(collagen)
None
Not preferred for Large bore
2.3 hrs.
2.5 hrs.
2.6 hrs.
2.3 hrs.
4-6 hrs.
Book a Clinical Evaluation in Your Region
Championed by Experts:
The Advanced Choice in Vascular Closure
”I did a peripheral arterial procedure today on a patient with severe generalized disease. This included a significant burden of calcification in both CFA requiring an antegrade approach. I utilized a SiteSeal® closure device to close the arteriotomy site. Without the unique advantages of the SiteSeal® design, external compression would have had to be utilized, and all endovascular physicians understand the associated disadvantages of external compression.”
”SiteSeal® has been a major difference at our program here for several reasons. One of the biggest ones is the ability to move patients in and out of the Cath Lab much quicker.”
”I had the opportunity to evaluate a new EP closure device, SiteSeal®, that closes multiple sheaths within a single vessel. I decided to do a comparison study between SiteSeal® and the closure device I was presently utilizing. The comparison evaluated safety, efficacy, complications, patient comfort and cost. Fifty patients per each device were compared. Based on the evaluation of comparison study, I plan to use SiteSeal® in my practice.”
Championed by Experts:
The Advanced Choice in
Vascular Closure
”I did a peripheral arterial procedure today on a patient with severe generalized disease. This included a significant burden of calcification in both CFA requiring an antegrade approach. I utilized a SiteSeal® closure device to close the arteriotomy site. Without the unique advantages of the SiteSeal® design, external compression would have had to be utilized, and all endovascular physicians understand the associated disadvantages of external compression.”
”SiteSeal® has been a major difference at our program here for several reasons. One of the biggest ones is the ability to move patients in and out of the Cath Lab much quicker.”
”I had the opportunity to evaluate a new EP closure device, SiteSeal®, that closes multiple sheaths within a single vessel. I decided to do a comparison study between SiteSeal® and the closure device I was presently utilizing. The comparison evaluated safety, efficacy, complications, patient comfort and cost. Fifty patients per each device were compared. Based on the evaluation of comparison study, I plan to use SiteSeal® in my practice.”
Why Patients Love SiteSeal®:
Comfort, Safety, and Peace of Mind
Patient-Centric Care with SiteSeal® – Ensuring optimal outcomes and a smooth recovery for every patient, setting new standards in patient care and clinical outcomes.
Significantly reduce recovery time for EP procedures. SiteSeal® allows immediate mobility, eating, and drinking for a more comfortable recovery.
Nothing Left Behind, Nothing Left to Chance
Significantly reduce recovery time for EP procedures. SiteSeal® allows immediate mobility, eating, and drinking for a more comfortable recovery.
Nothing Left Behind, Nothing Left to Chance
Designed for All Patients